AN ADAPTIVE TWO-ARM CLINICAL TRIAL USING EARLY ENDPOINTS TO INFORM DECISION MAKING: DESIGN FOR A STUDY OF SUB-ACROMIAL SPACERS FOR REPAIR OF ROTATOR CUFF TENDON TEARS

An adaptive two-arm clinical trial using early endpoints to inform decision making: design for a study of sub-acromial spacers for repair of rotator cuff tendon tears

Abstract Background There is widespread concern across the clinical and research communities that clinical trials, powered for patient-reported outcomes, testing new surgical procedures are often expensive and time-consuming, particularly when the new intervention is shown to be no better than the standard.Conventional (non-adaptive) randomised con

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